Movement and Neurodegenerative Diseases - DocNeuro

MSA hot cross buns sign

Naoum P. Issa MD PhD — Tue, 29 Jul 2014 17:12:41 +0000

Multi-systems atrophy is a progressive neurodegenerative disorder often initially difficult to differentiate from Parkinson’s Disease. Patients present with autonomic instability (fainting due to orthostasis, fluctuating heart rate, urinary incontinence or difficulty emptying bladder) and movement disorders (tremor, rigidity, ataxia). MSA is further classified into cerebellar predominant (MSA-C) or Parkinsonian predominant (MSA-P) depending on the primary […]

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Creutzfeld-Jacob Disease

Stasia Rouse MD — Tue, 21 May 2013 23:28:00 +0000

Creutzfeld-Jacob disease is a rapidly progressive spongiform degeneration of the brain due to the accumulation of misfolded prion proteins (PRNP). The human prion diseases that have been described include: Creutzfeld-Jacob disease (CJD) Variant Creutzfeld-Jacob disease (vCJD) Kuru (New Guinea) Gerstmann-Straussler-Scheinker disease (GSS) Fatal Familial Insomnia (FFI) Several prion diseases occur in animals including bovine spongiform […]

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Restless leg syndrome

Stasia Rouse MD — Sat, 18 May 2013 02:02:08 +0000

Restless leg syndrome (RLS) is a common neurological disorder with a prevalence of 5 to 10%. A sensorimotor disorder characterized by the urge to move one’s legs often accompanied by uncomfortable, unpleasant leg sensations, RLS can disrupt sleep and as a result impair daytime quality of life. Diagnostic features restless leg syndrome The following features are […]

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Drug Therapy for Alzheimer’s Dementia

Dipika Oberoi MD — Fri, 29 Mar 2013 12:34:51 +0000

Alzheimer’s dementia (AD) is the most common cause of dementia in western society. Disease specific treatments that are currently available do not appear to alter the course of the illness, though may slow or delay progression. Cholinesterase inhibitors and N-methyl-D-aspartate (NMDA) receptor antagonists are the only two classes of drugs currently approved by the FDA for […]

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Evaluating Tremors

Dipika Oberoi MD — Mon, 18 Mar 2013 16:03:03 +0000

Tremors are the most common movement disorder encountered in clinical practice and can be defined as an involuntary, rhythmic, oscillatory movement of a body part. While tremors predominantly affect the upper extremities (wrist, hands), tremors of the head, lower extremities, and voice can also be encountered. Classification Tremors can be broadly classified into rest and […]

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Vitamin B12 Deficiency

Naoum P. Issa MD PhD — Tue, 25 Sep 2012 22:41:47 +0000

Cobalamin (Vitamin B12) derivatives are cofactors in the synthesis of both amino acids and purines. B12 deficiencies, as a result, cause problems with both DNA and protein synthesis. Vitamin B12 and amino acid synthesis Cobalamin is a cofactor in the formation of methionine from homocysteine. There is a separate pathway to regenerate homocysteine from methionine […]

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