Inflammatory and Demyelinating Diseases - DocNeuro

ADEM

Christopher Buckle MD — Mon, 03 Feb 2014 04:01:38 +0000

ADEM (acute disseminated encephalomyelitis) is an autoimmune demyelinating disorder distinct from multiple sclerosis or Devic’s disease. Figure: Axial FLAIR at the level of the midbrain (A) and the thalamus (B) demonstrate increased signal in the left anteromedial thalamus (red arrow) and ventral midbrain (white arrow). Axial postcontrast T1 demonstrates no enhancement of the thalamic signal […]

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Tumefactive multiple sclerosis

Christopher Buckle MD — Sat, 07 Dec 2013 19:55:18 +0000

Tumefactive multiple sclerosis (MS) is an unusual but important manifestation of multiple sclerosis. This is a patient with tumefactive MS. Notice the incomplete rim enhancement around the right frontal mass on the T1 post contrast sequence. This incomplete rim enhancement is classic for a tumefactive demyelinating lesion as opposed to a neoplasm. A. T1 precontrast and […]

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Dr. Anthony Reder – advice for the resident and MS fellow

Rui Guan MD — Mon, 16 Sep 2013 21:15:48 +0000

Dr. Rui Guan interviews Dr. Anthony Reder, an MS specialist at the University of Chicago. This article, geared to residents and fellows, gives insight into Dr. Reder’s world. About Dr. Reder: Dr. Reder directs the Neurology and Inflammatory Disease Infusion Center at the University of Chicago and is an expert in multiple sclerosis, having written over a […]

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Chat with MS practice expert – Dr. Anthony Reder

Rui Guan MD — Mon, 16 Sep 2013 21:00:05 +0000

Multiple Sclerosis expert Dr. Anthony Reder from the University of Chicago Department of neurology is interviewed by Dr. Rui Guan on topics in MS of interest to neurologists and general practitioners alike. About Dr. Anthony Reder: Dr. Reder has authored or co-authored over 100 scientific papers on multiple sclerosis, ranging from the basic science of […]

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Expanded disability status score for MS

Rui Guan MD — Sat, 07 Sep 2013 14:59:14 +0000

Disability progression is assessed by the Expanded Disability Status Score (EDSS). To make sense of the scale from 0 (normal neuro exam) to 10 (death due to MS), a few pointers: 1-1.5 is no disability that the patient notes, e.g. decreased vibration sense or red desaturation 3-3.5, billed as “disability is mild to moderate,” but […]

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Uthoff’s phenomenon

Rui Guan MD — Sat, 07 Sep 2013 13:51:31 +0000

Uhthoff’s phenomenon describes the worsening of multiple sclerosis symptoms with overheating, e.g. exercise, hot weather, or saunas, which cause conduction delay or block in a demyelinated nerves. In practice, even a change in ambient body temperature by 0.5 degree can increase prior symptoms.

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MS update – September 2013

Rui Guan MD — Fri, 06 Sep 2013 15:26:39 +0000

“Multiple sclerosis (MS) does not really remit” was the opening theme of this weekend’s conference. Lead by three MS-experts, Drs. Omar Khan, Guy Buckle, and Stephen Krieger, a roomful of neurology residents reviewed the epidemiology, classification, immunopathogenesis, disease course and their impact on therapeutic advancement. MS does not remit – insights from pathology As MS […]

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Multiple Sclerosis

Rui Guan MD — Fri, 15 Mar 2013 20:48:28 +0000

MULTIPLE SCLEROSIS is aptly named for the scleroses (scars or plaques) that occur as the disease resurfaces in multiple episodes. Diagnosis of multiple sclerosis – the 2010 update The McDonald Criteria for diagnosing MS was updated in 2010 to help simplify the use of images, and in cases, use one MRI to establish dissemination in space and time […]

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Neurosarcoid

Christopher Buckle MD — Tue, 19 Feb 2013 20:47:54 +0000

Sarcoidosis is a systemic inflammatory condition with a specific pathology – non caseating (unlike TB) granulomas. The condition affects the lungs , bones and brain. Neurosarcoid occurs in about 5-10% of patients with sarcoidosis and is often asymptomatic, although may present with a myriad of neuropsychiatric symptoms, ranging from facial nerve palsy to depression. Leptomeningeal […]

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Bell’s Palsy

Naoum P. Issa MD PhD — Sat, 22 Dec 2012 20:55:08 +0000

An idiopathic palsy of the facial nerve (cranial nerve VII) which results in ipsilateral weakness of the facial muscles. Clinical Presentation of Bell’s Palsy Patients present with weakness and sometimes complete paralysis of the facial musculature on the side involved This can manifest as: Loss of the nasolabial fold and dropping of the corner of […]

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